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其他產(chǎn)品
其他產(chǎn)品

Phospho-Aconitase 1 (Ser711) Antibody

規(guī)格：50μl, 100μl

價(jià)格：￥1250/50μl, ￥2500/100μl

產(chǎn)品特性

數(shù)據(jù)表

UniProtP21399
Mol Weight98 Kda
Alternative NamesACO1, Aconitate hydratase, EC 4.2.1.3, Ferritin repressor protein, IRE-BP 1, IRE1, IREBP1, IRP1, aconitase, citrate hydro-lyase, iron regulatory protein 1, iron-responsive element binding protein 1
ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human IREB1 around the phosphorylation site of serine 711 (Y-G-SP-R-R).
StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
PurificationAffinity-chromatography
IsotypeRabbit IgG
ClonalityPolyclonal
DescriptionIron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.


Applications

ReactivityHuman:S711,Mouse:S711,Rat:S711
ApplicationWB,IHC,ELISA
Recommended dilutionWB: 1:500~1:3000 IHC: 1:50~1:100 ELISA: 1:10000
1698287279177320.jpgWestern blot analysis of extracts from 293 cells, treated with insulin (0.01U/ml, 30mins), using IREB1 (Phospho-Ser711) antibody.
1698287266612486.jpgImmunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using IREB1 (Phospho-Ser711) antibody.